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KMID : 1145120160140030249
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Asian Journal of Beauty and Cosmetology
2016 Volume.14 No. 3 p.249 ~ p.257
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Anti-aging Effect of Brazilin in UVA-irradiated Dermal Fibroblasts
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Shim Joong-Hyun
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Abstract
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Purpose: This research was carried out to identify the skin anti-aging effect of brazilin on dermal fibroblasts.
Methods: To investigate anti-aging effects of brazilin on dermal fibroblasts, we confirmed cell viability, mRNA expression, and ELISA assay (collagen, type I and MMP1).
Results: In this study, we elucidated the effects of brazilin on mRNA expression (COL1A1, COL3A1, MMP1, SOD1, SOD2, SOD2, and CAT) and on protein production (collagen, type I and MMP1). Quantitative Real-time RT-PCR showed that brazilin increased mRNA expression of COL1A1, COL3A1 and SOD3 genes and protein production of collagen, type I compared with UVA-treated dermal fibroblasts. Furthermore MMP1 mRNA and protein expressions were decreased by brazilin treatment. These observations revealed that brazilin increased anti-aging effects in dermal fibroblasts.
Conclusion: Therefore, we identified the anti-aging effects of brazilin, and this result showed that the brazilin can be a considerable potent ingredient for skin anti-aging. Based on this, we need to study further researches about mechanisms of brazilin to be developed for cosmetics, healthcare food, and medicine.
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KEYWORD
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Brazilin, Anti-aging, COL1A1, MMP1, SOD3
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